Cryptic crossword clue
Punched by right hand of Dempsey, strong thing felled — end of fight! 4

The most common and most likely answer to this crossword clue is the 4 letter word KAYO

I've seen this crossword clue in The Guardian
K
A
Y
O


Buddy explains!

The straight part
We know that "end of fight" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case end of fight = kayo.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does KAYO mean?

KAYO noun
  1. A knockout (in boxing).
KAYO verb
  1. To knock someone out, or render them unconscious or senseless.

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