The most common and most likely answer to this crossword clue is the 6 letter word IPECAC
I've seen this crossword clue in The Guardian
I
P
E
C
A
C
More clues leading to the result IPECAC
- Reject a mushroom in Jersey etc — it’ll make youretch
- Emetic plant product secreted by overripe cactus
- In parliament, even Conservatives attack current leaders – it makes you sick
- Melting icecap that’s hard to stomach
- Purgative from island vegetable
- It makes you sick to see ice cap melting
- Drug I accept will work, getting rid of torment finally
- Unripe cactus extract will make you sick
- Stir a cc of eggnog initially into pale ale – it’ll make you sick!
- This dried root may flourish with rain in picnic area
Buddy explains!
The straight part
We know that "Purgative/Purgative" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case purgative/purgative = ipecac.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does IPECAC mean?
IPECAC noun- The plant ipecacuanha (Psychotria ipecacuanha) or its root.
- Syrup of ipecac, produced from this plant's root, used to induce emesis (vomiting).