Cryptic crossword clue
Purgative, in the manner of penetrating justice 5

The most common and most likely answer to this crossword clue is the 5 letter word JALAP

J
A
L
A
P

Buddy explains!

The straight part
We know that "Purgative" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case purgative = jalap.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does JALAP mean?

JALAP noun
  1. A cathartic drug consisting of the tuberous roots of Ipomoea purga, a convolvulaceous plant found in Mexico.
JALAP noun
  1. A jalapeƱo.

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