Cryptic crossword clue
Put an end to trusted criminal carrying drug 8

The most common and most likely answer to this crossword clue is the 8 letter word DESTRUCT

I've seen this crossword clue in The Guardian
D
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Buddy explains!

The straight part
We know that "Put an end to" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case put an end to = destruct.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DESTRUCT mean?

DESTRUCT verb
  1. To intentionally cause the destruction of.
  2. To self-destruct.

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