Cryptic crossword clue
Put in charge of various nutters

The most common and most likely answer to this crossword clue is the 7 letter word ENTRUST

I've seen this crossword clue in Independent
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The straight part
We know that "Put in charge of" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case put in charge of = entrust.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENTRUST mean?

ENTRUST verb
  1. To trust to the care of.

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