Cryptic crossword clue
Put out of action by college head, mostly prepare university lecturer to quit 10

The most common and most likely answer to this crossword clue is the 10 letter word DEACTIVATE

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Buddy explains!

The straight part
We know that "Put out of action" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case put out of action = deactivate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DEACTIVATE mean?

DEACTIVATE verb
  1. To make something inactive or no longer effective
  2. To prevent the action of a biochemical agent (such as an enzyme)
  3. To remove a person or piece of hardware from active military service

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