The most common and most likely answer to this crossword clue is the 6 letter word CHANGE
I've seen this crossword clue in The Guardian
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More clues leading to the result CHANGE
Buddy explains!

The straight part
We know that "it may be loose /it may be loose" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it may be loose /it may be loose = change.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CHANGE mean?
CHANGE noun- The process of becoming different.
- Small denominations of money given in exchange for a larger denomination.
- A replacement, e.g. a change of clothes
- Balance of money returned from the sum paid after deducting the price of a purchase.
- Usually coins (as opposed to paper money), but sometimes inclusive of paper money
- A transfer between vehicles.
- A change-up pitch.
- (campanology) Any order in which a number of bells are struck, other than that of the diatonic scale.
- A place where merchants and others meet to transact business; an exchange.
- A public house; an alehouse.
- To become something different.
- To make something into something else.
- To replace.
- To replace one's clothing.
- To replace the clothing of (the one wearing it).
- To transfer to another vehicle (train, bus, etc.)
- To exchange.
- To change hand while riding (a horse).