Cryptic crossword clue
Quack doctor holding job in Iran 8

The most common and most likely answer to this crossword clue is the 8 letter word IMPOSTOR

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "Quack" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case quack = impostor.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IMPOSTOR mean?

IMPOSTOR noun
  1. Someone who attempts to deceive by using an assumed name or identity.
  2. A sprite or animation integrated into a three-dimensional scene, but not based on an actual 3D model.

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