The most common and most likely answer to this crossword clue is the 4 letter word MARY
I've seen this crossword clue in The Guardian
M
A
R
Y
More clues leading to the result MARY
- Sheep knocked over Yankee woman held in reverence
- Woman to wed right away
- Girl, to become wife, runs out
- His mum’s Conservative leader embracing Republican
- Girl to wed right away
- Gin: mother’s ruin merely started with yen
- Sheep turned on Yankee woman
- Girl to wed, having given heart away
- Queen is allowed to imprison republican
- Queen arm-twisted Yankee
Buddy explains!

The straight part
We know that "Queen" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case queen = mary.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MARY mean?
MARY noun- (usually capitalized) A male homosexual.