The most common and most likely answer to this crossword clue is the 6 letter word ENRICH
I've seen this crossword clue in The Times
E
N
R
I
C
H
More clues leading to the result ENRICH
- Queen Richelieu has to make wealthy
- Improve quality of garden Richelieu used to some extent
- Make wealthy leaders of English nobility remain in city homes
- Swell the coffers of Henri Charrière to some extent
- Better when Focke, perhaps, loses height
- Refine garden Richelieu used to an extent
- Russian leader in niche organisation to improve wealth
- Give money to Caruso, say, but not O. Henry
- Improve in hour after noon in Clapton?
- Decorate Caruso’s unfinished hotel
Buddy explains!

The straight part
We know that "make wealthy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case make wealthy = enrich.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ENRICH mean?
ENRICH verb- To enhance.
- To make (someone or something) rich or richer.
- To adorn, ornate more richly.
- To add nutrients or fertilizer to the soil; to fertilize.
- To increase the amount of one isotope in a mixture of isotopes, especially in a nuclear fuel.
- To add nutrients to foodstuffs; to fortify
- To make to rise the proportion of a given constituent.
- To add new elements, to complete.