Cryptic crossword clue
Quickly finish drink by moving arm, set towards mouth 10

The most common and most likely answer to this crossword clue is the 10 letter word DOWNSTREAM

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "towards mouth" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case towards mouth = downstream.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DOWNSTREAM mean?

DOWNSTREAM verb
  1. To stream downward.
DOWNSTREAM adjective
  1. Lower down, in relation to a river, stream or flow of fluid
  2. In the direction from the server to the client.
  3. Towards the 3' end of a DNA molecule.
  4. (metaphoric) Influenced by something; being a consequence of something.
DOWNSTREAM adverb
  1. Following the path of a river or stream

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