Cryptic crossword clue
Radio and TV broadcast must include Home Is Where The Heart Is 11

The most common and most likely answer to this crossword clue is the 11 letter word MEDIASTINUM

I've seen this crossword clue in The Guardian
M
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Buddy explains!

The straight part
We know that "Where The Heart Is" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case where the heart is = mediastinum.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MEDIASTINUM mean?

MEDIASTINUM noun
  1. The region in mammals between the pleural sacs, containing the heart and all of the thoracic viscera except the lungs.

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