Cryptic crossword clue
Raise second quote about hard philosophical investigations 6

The most common and most likely answer to this crossword clue is the 6 letter word ETHICS

I've seen this crossword clue in Independent
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The straight part
We know that "philosophical investigations" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case philosophical investigations = ethics.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ETHICS mean?

ETHICS noun
  1. The study of principles relating to right and wrong conduct.
  2. Morality.
  3. The standards that govern the conduct of a person, especially a member of a profession.

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