Cryptic crossword clue
Reason you finally departed — no longer having job leading 11

The most common and most likely answer to this crossword clue is the 11 letter word EXPOSTULATE

I've seen this crossword clue in The Guardian
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The straight part
We know that "Reason" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case reason = expostulate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EXPOSTULATE mean?

EXPOSTULATE verb
  1. To protest or remonstrate; to reason earnestly with a person on some impropriety of conduct.

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