The most common and most likely answer to this crossword clue is the 2 plus 2 plus 5 letter word ET TU BRUTE
I've seen this crossword clue in Independent
E
T
T
U
B
R
U
T
E
More clues leading to the result ET TU BRUTE
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- You’ve let me down, putting rotten butter on butties regularly
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- Speak briefly about barbarian emperor’s final words
Buddy explains!
The straight part
We know that "Shakespeare quotation/ (2,2,5)" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case shakespeare quotation/ (2,2,5) = et tu brute.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.