Cryptic crossword clue
Red standing for reform, filled with dread 5-6

The most common and most likely answer to this crossword clue is the 12 letter word ANGST-RIDDEN

I've seen this crossword clue in The Times
A
N
G
S
T
-
R
I
D
D
E
N

Buddy explains!

The straight part
We know that "filled with dread" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case filled with dread = angst-ridden.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ANGST-RIDDEN mean?

ANGST-RIDDEN adjective
  1. Dominated or plagued by angst.

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