Cryptic crossword clue
Refreshing change for vegan retiree 12

The most common and most likely answer to this crossword clue is the 12 letter word REGENERATIVE

I've seen this crossword clue in The Guardian
R
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Buddy explains!

The straight part
We know that "Refreshing" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case refreshing = regenerative.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does REGENERATIVE mean?

REGENERATIVE adjective
  1. That serves to regenerate.
  2. Being a kind of circuit, much used in radio receivers, that allows an electronic signal to be amplified many times through a feedback loop.

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