Cryptic crossword clue
Refusal of agreement to keep Irish province 6

The most common and most likely answer to this crossword clue is the 6 letter word DENIAL

I've seen this crossword clue in The Guardian
D
E
N
I
A
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Buddy explains!

The straight part
We know that "Refusal" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case refusal = denial.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DENIAL mean?

DENIAL noun
  1. The negation in logic.
  2. A refusal to comply with a request.
  3. An assertion of untruth.
  4. Refusal to believe a problem exists
  5. A defense mechanism involving a refusal to accept the truth of a phenomenon or prospect.

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