Cryptic crossword clue
Refusal to compromise, Irene can’t sign anyway 13

The most common and most likely answer to this crossword clue is the 13 letter word INTRANSIGENCE

I've seen this crossword clue in The Daily Telegraph
I
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Buddy explains!

The straight part
We know that "Refusal to compromise" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case refusal to compromise = intransigence.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INTRANSIGENCE mean?

INTRANSIGENCE noun
  1. Unwillingness to change one's views or to agree.

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