Cryptic crossword clue
Refusing to give in the end natural 8

The most common and most likely answer to this crossword clue is the 8 letter word STUBBORN

I've seen this crossword clue in The Times
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The straight part
We know that "Refusing to give" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case refusing to give = stubborn.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does STUBBORN mean?

STUBBORN noun
  1. Stubbornness.
  2. A disease of citrus trees characterized by stunted growth and misshapen fruit, caused by Spiroplasma citri.
STUBBORN adjective
  1. Refusing to move or to change one's opinion; obstinate; firmly resisting; persistent in doing something.
  2. Of materials: physically stiff and inflexible; not easily melted or worked.

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