The most common and most likely answer to this crossword clue is the 5 letter word INURE
I
N
U
R
E
More clues leading to the result INURE
- Toughen up one sister, maybe, not second
- Judge, escaping harm, has to get tougher
- Come into effect after section’s deleted from guarantee
- Get hardened like Wensleydale swimmers?
- Condition in old city quarter
- Get used to guarantee not having succeeded
- Toughen up concerning cut by university
- Get used to being in old city quarter
- Get used to cool prime pieces of turkey
- Harden against some from Manchester United making a comeback
Buddy explains!
The straight part
We know that "come into effect" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case come into effect = inure.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does INURE mean?
INURE verb- To cause someone to become accustomed to something (usually) unpleasant.
- To take effect, to be operative.
- To commit.