Cryptic crossword clue
Regrets spoilage, so breaks down 10

The most common and most likely answer to this crossword clue is the 10 letter word APOLOGISES

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Buddy explains!

The straight part
We know that "Regrets" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case regrets = apologises.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does APOLOGISES mean?

APOLOGISES verb
  1. (often followed by “for”) To make an apology or excuse; to acknowledge some fault or offense, with expression of regret for it, by way of amends
  2. To express regret that a certain event has occurred.
  3. To make an apologia or defense; to act as apologist.

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