The most common and most likely answer to this crossword clue is the 5 plus 6 letter word HALF- SISTER
H
A
L
F
-
S
I
S
T
E
R
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does HALF- SISTER mean?
HALF- SISTER noun- A female sibling sharing a single parent.