Cryptic crossword clue
Religious leader investigates head of Trinity 6

The most common and most likely answer to this crossword clue is the 5 letter word PRIES

I've seen this crossword clue in The Daily Telegraph
P
R
I
E
S

Buddy explains!

The straight part
We know that "Religious leader" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case religious leader = pries.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PRIES mean?

PRIES verb
  1. To look where one is not welcome; to be nosy.
  2. To keep asking about something that does not concern one.
  3. To look closely and curiously at (something closed or not public).
PRIES verb
  1. To use leverage to open or widen.

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