Cryptic crossword clue
Remote agent returns after South Africa quiet 6

The most common and most likely answer to this crossword clue is the 6 letter word ZAPPER

Z
A
P
P
E
R

Buddy explains!

The straight part
We know that "Remote" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case remote = zapper.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ZAPPER mean?

ZAPPER noun
  1. A remote control for a television.
  2. A device that electrocutes ("zaps") with a high voltage, e.g. a bug zapper.
  3. (by extension) Anything that exterminates.

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