Cryptic crossword clue
Remove feeling of extremes of discomfiture with port 6

The most common and most likely answer to this crossword clue is the 6 letter word DEADEN

I've seen this crossword clue in Financial Times
D
E
A
D
E
N

Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DEADEN mean?

DEADEN verb
  1. To render less lively; to diminish; to muffle.
  2. To become less lively; to diminish (by itself).
  3. To make soundproof.

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