The most common and most likely answer to this crossword clue is the 10 letter word CHECKMATED
I've seen this crossword clue in The Guardian
C
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More clues leading to the result CHECKMATED
Buddy explains!

The straight part
We know that "totally frustrated" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case totally frustrated = checkmated.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CHECKMATED mean?
CHECKMATED verb- To put the king of an opponent into checkmate.
- (by extension) To place in a losing situation that has no escape.
- Having a king in check with no possible move to escape check, thus losing the game.
- Suffering a personal loss with no obvious chance to escape the loss.