The most common and most likely answer to this crossword clue is the 6 letter word IGUANA
I've seen this crossword clue in The Times
I
G
U
A
N
A
More clues leading to the result IGUANA
- Reptile disfiguring canal’s central parts
- Crested lizard one year vanishing from country
- Reptile seen in Antigua naturally?
- Reptile, one to the fore in S American region
- Refresh again after plugging in universal monitor
- Lizards wandering in Nicaragua avoiding vehicle
- Lizard droppings mostly found in Iowa
- Reptile of Antiguan antiquity
- Lizard, one climbing in South American region
- Creature‘s droppings mostly deposited in middle of aviary
Buddy explains!

The straight part
We know that "Reptile" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case reptile = iguana.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does IGUANA mean?
IGUANA noun- A green iguana (Iguana iguana), a large tropical American lizard often kept as a pet
- In zoology, any member of the genus Iguana
- Colloquially, in America and the Pacific, any of several members of the lizard family Iguanidae.
- Colloquially, in Africa, any large member of the genus Varanus, especially the aquatic Nile monitor -- see leguan
- Colloquially, in Australia, any member of the genus Varanus -- see goanna