Cryptic crossword clue
Reptile protects its own head at the earliest opportunity 4

The most common and most likely answer to this crossword clue is the 4 letter word ASAP

A
S
A
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Buddy explains!

The straight part
We know that "at the earliest opportunity" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case at the earliest opportunity = asap.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ASAP mean?

ASAP adverb
  1. As soon as is possible; at one's earliest convenience; at the earliest possible time.

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