Cryptic crossword clue
Reptile struggling alone 5

The most common and most likely answer to this crossword clue is the 5 letter word ANOLE

A
N
O
L
E

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The straight part
We know that "Reptile" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case reptile = anole.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ANOLE mean?

ANOLE noun
  1. Any of the Anolis genus of arboreal American lizards (such as the American chameleon) from the iguana family which feature a brightly colored dewlap and color-changing ability.

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