Cryptic crossword clue
Reptile that man caught at last, working with hook and loops 7

The most common and most likely answer to this crossword clue is the 7 letter word CROCHET

C
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Buddy explains!

The straight part
We know that "working with hook and loops" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case working with hook and loops = crochet.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CROCHET mean?

CROCHET noun
  1. Needlework made by looping thread with a hooked needle.
  2. A certain crest of enamel on the molar teeth of some rhinoceros.
CROCHET verb
  1. To make (a piece of) needlework using a hooked needle; to make interlocking loops of thread.

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