The most common and most likely answer to this crossword clue is the 11 letter word RATTLESNAKE
I've seen this crossword clue in The Daily Telegraph
R
A
T
T
L
E
S
N
A
K
E
More clues leading to the result RATTLESNAKE
- US poisoner discomfits nude getting bottom pinched
- Poisonous reptile disconcerts nude no end
- Creepy type is disconcerting, flagrant with pinching of bottom
- Eternal task diverting a venomous reptile
- Vigorous eternal task for American viper
- Reptile unnerves nude no doubt, at first
- Virulent type provokes earnest talk
- Serpent appears as dissolute man, talents cunningly concealed
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does RATTLESNAKE mean?
RATTLESNAKE noun- Any of various venomous American snakes, of genera Crotalus and Sistrurus, having a rattle at the end of its tail.