Cryptic crossword clue
Republican’s second in command, please reply 4

The most common and most likely answer to this crossword clue is the 4 letter word RSVP

I've seen this crossword clue in The Guardian
R
S
V
P

Buddy explains!

The straight part
We know that "please reply" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case please reply = rsvp.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RSVP mean?

RSVP verb
  1. To reply to an invitation.
RSVP verb
  1. (restaurants, events) To reserve a place

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