Cryptic crossword clue
Respond amiably to fool over satisfying role 4,2,4,4

The most common and most likely answer to this crossword clue is the 4 plus 2 plus 4 plus 4 letter word TAKE IN GOOD PART

I've seen this crossword clue in The Daily Telegraph
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Buddy explains!

The straight part
We know that "Respond amiably" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case respond amiably = take in good part.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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