The most common and most likely answer to this crossword clue is the 8 letter word CULPABLE
I've seen this crossword clue in The Guardian
C
U
L
P
A
B
L
E
Buddy explains!
The straight part
We know that "Responsible" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case responsible = culpable.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CULPABLE mean?
CULPABLE adjective- Meriting condemnation, censure or blame, especially as something wrong, harmful or injurious; blameworthy.