The most common and most likely answer to this crossword clue is the 7 letter word BEDSORE
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More clues leading to the result BEDSORE
Buddy explains!
The straight part
We know that "Result of chafing when you’re not up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case result of chafing when you’re not up = bedsore.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does BEDSORE mean?
BEDSORE noun- (usually in plural) A lesion caused by unrelieved pressure to any part of the body, especially portions over bony or cartilaginous areas, such as frequently develops on a person confined to a bed by infirmity.