The most common and most likely answer to this crossword clue is the 16 letter word LOW-SPIRITEDNESS
I've seen this crossword clue in The Guardian
L
O
W
-
S
P
I
R
I
T
E
D
N
E
S
S
Buddy explains!
The straight part
We know that "Result of depression whilst husband’s away? Could be" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case result of depression whilst husband’s away? could be = low-spiritedness.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.