The most common and most likely answer to this crossword clue is the 12 letter word ESTRANGEMENT
I've seen this crossword clue in The Sunday Telegraph
E
S
T
R
A
N
G
E
M
E
N
T
More clues leading to the result ESTRANGEMENT
- Weirdos, perhaps, absorbed by Yvette’s centre parting
- Separation of weird blokes in Egypt’s borders
- Disunity of odd blokes in sci-fi film
- Alienation from agreements not lacking substance
- Soldiers on mountains in test about alienation
- Alienation of odd people adopted by sect regularly
- Result of splitting up in toughest range men tackled
- Disaffection of irregular soldiers captured by 26
- Eastern syndicate’s head smuggled precious item into camp for removal
- Is in France facing mountains with soldiers — time for isolation
Buddy explains!
The straight part
We know that "Result of splitting up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case result of splitting up = estrangement.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ESTRANGEMENT mean?
ESTRANGEMENT noun- The act of estranging; the act of alienating; alienation.
- The state of being alien; foreign, non-native.