Cryptic crossword clue
Retaliation of noble time and time again on course

The most common and most likely answer to this crossword clue is the 13 letter word COUNTERATTACK

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "Retaliation" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case retaliation = counterattack.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does COUNTERATTACK mean?

COUNTERATTACK noun
  1. An attack made in response to an attack by the opponents
COUNTERATTACK verb
  1. To attack in response to an attack by opponents

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