Cryptic crossword clue
Reverse the setting up of one vulgar doctor 5

The most common and most likely answer to this crossword clue is the 5 letter word UNRIG

I've seen this crossword clue in The Guardian
U
N
R
I
G


Buddy explains!

The straight part
We know that "Reverse the setting up/one" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case reverse the setting up/one = unrig.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UNRIG mean?

UNRIG verb
  1. To remove the rigging from (a vessel, etc.).
  2. To disable.
  3. To undress (someone).

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