The most common and most likely answer to this crossword clue is the 3 plus 8 letter word DON GIOVANNI
I've seen this crossword clue in Independent
D
O
N
G
I
O
V
A
N
N
I
Buddy explains!
The straight part
We know that "opera" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case opera = don giovanni.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.