The most common and most likely answer to this crossword clue is the 8 letter word FRECKLES
I've seen this crossword clue in The Times
F
R
E
C
K
L
E
S
More clues leading to the result FRECKLES
Buddy explains!

The straight part
We know that "spots" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case spots = freckles.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does FRECKLES mean?
FRECKLES noun- A small brownish or reddish pigmentation spot on the surface of the skin.
- Any small spot or discoloration.
- A small sweet consisting of a flattish mound of chocolate covered in hundreds and thousands.
- The anus.