Cryptic crossword clue
River bug, most affected 7

The most common and most likely answer to this crossword clue is the 7 letter word CAMPEST

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Buddy explains!

The straight part
We know that "most affected" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most affected = campest.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CAMPEST mean?

CAMPEST adjective
  1. Theatrical; making exaggerated gestures.
  2. (of a man) Ostentatiously effeminate.
  3. Intentionally tasteless or vulgar, self-parodying.

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