The most common and most likely answer to this crossword clue is the 4 letter word ELBE
E
L
B
E
More clues leading to the result ELBE
- Flower spotted in Heidelberg
- German banker resident in Heidelberg
- River flowing through German university city
- Eels bred in odd places in river
- Flow revealed by Daniel Bernouilli
- European banker entering hotel bedroom
- Banker model bedded after strip shows
- Well able to dump odd characters in river
- River coming into hovel below
- What’s held by Continental banks? Euro’s first, pound sterling’s third
Buddy explains!

The straight part
We know that "River flowing through German university city" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case river flowing through german university city = elbe.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.