The most common and most likely answer to this crossword clue is the 5 letter word EDEMA
E
D
E
M
A
More clues leading to the result EDEMA
- River swelled by rising sea, unhealthy accumulation of fluid
- Pathological bloatedness, feature of excessive demagoguery
- Swelling fame delays turning up in part
- Dropsy ‘became debilitating’ — internal evidence seen in retrospect
- Rising sea fills channel causing accumulation of fluid
- Dropsy obtained by oriental made crazy
- Swelling a bit, excitedly made out
Buddy explains!

The straight part
We know that "accumulation of fluid" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case accumulation of fluid = edema.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does EDEMA mean?
EDEMA noun- An excessive accumulation of serum in tissue spaces or a body cavity.
- A similar swelling in plants caused by excessive accumulation of water.