Cryptic crossword clue
Room heir had to get refurbished for pile

The most common and most likely answer to this crossword clue is the 11 letter word HAEMORRHOID

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "pile" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case pile = haemorrhoid.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HAEMORRHOID mean?

HAEMORRHOID noun
  1. (often in the plural) An engorged, dilated and easily broken varicosity in the perianal area, often accompanied by intense itching and throbbing pain: piles.

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