Cryptic crossword clue
Rose more sick swallowing a tablet? 10

The most common and most likely answer to this crossword clue is the 10 letter word PAINKILLER

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "tablet?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case tablet? = painkiller.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PAINKILLER mean?

PAINKILLER noun
  1. A drug that numbs the pain in the body.

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