Cryptic crossword clue
Rough drink satisfied his loss of heart

The most common and most likely answer to this crossword clue is the 5 letter word METHS

I've seen this crossword clue in The Guardian
M
E
T
H
S

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The straight part
We know that "Rough drink" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case rough drink = meths.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does METHS mean?

METHS noun
  1. Methylated spirits.
METHS noun
  1. Methamphetamine, especially in the form of the crystalline hydrochloride.
METHS noun
  1. Methadone.
METHS noun
  1. (Mancunian) A tramp.
METHS noun
  1. A spiced mead, originally from Wales.

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