Cryptic crossword clue
Rough pelt sash is most likely to cause spots 10

The most common and most likely answer to this crossword clue is the 10 letter word SPLASHIEST

I've seen this crossword clue in Financial Times
S
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Buddy explains!

The straight part
We know that "most likely to cause spots" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most likely to cause spots = splashiest.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SPLASHIEST mean?

SPLASHIEST adjective
  1. Relating to making splashes or the sound of splashing.
  2. Showy, ostentatious.
  3. Splashed with color.
  4. Wet and muddy; full of dirty water.

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