Cryptic crossword clue
Round trip’s constant touring via manic scrambling 16

The most common and most likely answer to this crossword clue is the 16 letter word CIRCUMNAVIGATION

I've seen this crossword clue in The Times
C
I
R
C
U
M
N
A
V
I
G
A
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O
N

Buddy explains!

The straight part
We know that "Round trip" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case round trip = circumnavigation.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CIRCUMNAVIGATION mean?

CIRCUMNAVIGATION noun
  1. The act of circumnavigating, or sailing round.

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